Sulfimycin

Generic Name: erythromycin and sulfisoxazole (ee RITH roe MYE sin and SUL fa SOX i zole)

Brand Names: Pediazole

What is Sulfimycin (erythromycin and sulfisoxazole)?

Erythromycin is in a group of drugs called macrolide antibiotics. Erythromycin fights bacteria in the body.

Sulfisoxazole is a sulfa drug that also fights bacteria in the body.

The combination of erythromycin and sulfisoxazole is used to ear infections in children.

Erythromycin and sulfisoxazole may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Sulfimycin (erythromycin and sulfisoxazole)?

Do not take this medication if you are allergic to erythromycin or sulfisoxazole, if you are in your 9th month of pregnancy, or if you are breast-feeding a baby younger than 2 months old.

Before taking erythromycin and sulfisoxazole, tell your doctor if you have liver or kidney disease, diabetes, myasthenia gravis, a history of "Long QT Syndrome," or if you are allergic to sulfa drugs or other antibiotics such as azithromycin (Zithromax) or clarithromycin (Biaxin).

Take this medication for the full prescribed length of time. Your symptoms may get better before the infection is completely cleared. Erythromycin and sulfisoxazole will not treat a viral infection such as the common cold or flu.

What should I discuss with my healthcare provider before taking Sulfimycin (erythromycin and sulfisoxazole)?

Do not take this medication if you are allergic to erythromycin or sulfisoxazole, or if::

• 
  

  you are in your 9th month of pregnancy; or

  
  


• 
  

  you are breast-feeding a baby younger than 2 months old.

  
  

Erythromycin may interact with these medicines and could cause dangerous or life-threatening heart rhythm disorders.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:

• kidney disease;


• 
  

  liver disease;

  
  


• 
  

  diabetes;

  
  


• 
  

  myasthenia gravis;

  
  


• 
  

  a history of "Long QT Syndrome"; or

  
  


• 
  

  if you are allergic to sulfa drugs or other antibiotics such as azithromycin (Zithromax) or clarithromycin (Biaxin).

  
  

FDA pregnancy category C. It is not known whether erythromycin and sulfisoxazole is harmful to an unborn baby when taken in early pregnancy. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. Do not take erythromycin and sulfisoxazole during late pregnancy. Erythromycin and sulfisoxazole can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not take erythromycin and sulfisoxazole if you are breast-feeding a baby younger than 2 months old. Older adults may be more likely to have side effects from this medication. Do not give this medication to a child younger than 2 months old.

How should I take Sulfimycin (erythromycin and sulfisoxazole)?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Take erythromycin and sulfisoxazole with a full glass (8 ounces) of water. Drink plenty of fluids every day while taking this medication.

Take this medication with food or milk if it upsets your stomach.

Shake the liquid medicine well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Erythromycin and sulfisoxazole is usually given 3 or 4 times daily. Try to take the medicine at evenly spaced intervals throughout the day.

Take this medication for the full prescribed length of time. Your symptoms may get better before the infection is completely cleared. Erythromycin and sulfisoxazole will not treat a viral infection such as the common cold or flu. If you need to have any type of surgery, tell the surgeon ahead of time that you are using erythromycin and sulfisoxazole. You may need to stop using the medicine for a short time.

Erythromycin and sulfisoxazole can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using erythromycin.

Store this medication in the refrigerator. Do not freeze. Throw away any unused medicine that is older than 14 days

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include dizziness, drowsiness, loss of appetite, nausea, vomiting, diarrhea, ringing in your ears, headache, stomach pain, fever, and fainting.

What should I avoid while taking Sulfimycin (erythromycin and sulfisoxazole)?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, stop taking this medication and call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Avoid exposure to sunlight, sunlamps, or tanning beds. Erythromycin and sulfisoxazole can make your skin more sensitive to sunlight, and a sunburn may result. Wear protective clothing and use sunscreen (SPF 15 or higher) when you are outdoors.

Sulfimycin (erythromycin and sulfisoxazole) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  dizziness, fainting, fast or pounding heartbeat;

  
  


• 
  

  diarrhea that is watery or bloody;

  
  


• 
  

  confusion, hallucinations;

  
  


• 
  

  muscle pain, tenderness, or weakness with fever or flu symptoms and dark colored urine;

  
  


• 
  

  white patches or sores inside your mouth or on your lips;

  
  


• 
  

  fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;

  
  


• 
  

  the first sign of any skin rash, no matter how mild;

  
  


• 
  

  pale skin, easy bruising or bleeding;

  
  


• 
  

  ringing in your ears, or problems with hearing;

  
  


• 
  

  numbness or tingly feeling in your hands or feet;

  
  


• 
  

  sore throat, swelling or lump in your throat or neck;

  
  


• 
  

  cough, feeling short of breath;

  
  


• 
  

  blood in your urine, pain in your side or lower back, pain when you urinate;

  
  


• 
  

  urinating less than usual or not at all; or

  
  


• 
  

  nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

  
  

Less serious side effects may include:

• 
  

  mild nausea, vomiting, diarrhea, or stomach pain;

  
  


• 
  

  headache, mild dizziness, spinning sensation; or

  
  


• 
  

  vaginal itching or discharge.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Sulfimycin (erythromycin and sulfisoxazole)?

Many drugs can interact with erythromycin. Below is just a partial list. Tell your doctor if you are using:

• 
  

  bromocriptine (Parlodel);

  
  


• 
  

  colchicine (Colcrys);

  
  


• 
  

  alprazolam (Xanax), midazolam (Versed), or triazolam (Halcion);

  
  


• 
  

  a blood thinner such as warfarin (Coumadin);

  
  


• 
  

  cyclosporine (Gengraf, Neoral, Sandimmune);

  
  


• 
  

  digoxin (Lanoxin);

  
  


• 
  

  methotrexate (Rheumatrex, Trexall);

  
  


• 
  

  theophylline (Elixophyllin, Theo-24, Uniphyl);

  
  


• 
  

  antifungal medication such as itraconazole (Sporanox), fluconazole (Diflucan), ketoconazole (Nizoral), or voriconazole (Vfend);

  
  


• 
  

  any other antibiotic, especially clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), levofloxacin (Levaquin), moxifloxacin (Avelox), or rifabutin (Mycobutin);

  
  


• 
  

  a blood thinner such as warfarin (Coumadin);

  
  


• 
  

  diabetes medication you take by mouth;

  
  


• 
  

  a diuretic (water pill);

  
  


• 
  

  a cholesterol-lowering medication such as lovastatin (Mevacor) or simvastatin (Zocor);

  
  


• 
  

  heart or blood pressure medication such as amiodarone (Cordarone, Pacerone), diltiazem (Cartia, Cardizem), dofetilide (Tikosyn), felodipine (Plendil), nifedipine (Nifedical, Procardia), sotalol (Betapace), or verapamil (Calan, Covera, Isoptin, Verelan);

  
  


• 
  

  heart rhythm medicine such as disopyramide (Norpace), procainamide (Procan, Pronestyl), propafenone (Rythmol), quinidine (Quinidex, Quin-Release Quin-G);

  
  


• 
  

  migraine headache medicine such as eletriptan (Relpax), ergotamine (Ercaf, Cafergot, Ergostat, Ergomar) or dihydroergotamine (D.H.E. 45, Migranal); or

  
  


• 
  

  seizure medication such as carbamazepine (Tegretol), phenytoin (Dilantin), or valproic acid (Depakote, Depakene).

  
  

This list is not complete and there are many other drugs that can interact with erythromycin and sulfisoxazole. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

More Sulfimycin resources

• Sulfimycin Use in Pregnancy & Breastfeeding
• Sulfimycin Drug Interactions
• Sulfimycin Support Group
• 0 Reviews for Sulfimycin - Add your own review/rating

• Eryzole Advanced Consumer (Micromedex) - Includes Dosage Information


• Pediazole MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Sulfimycin with other medications

• Otitis Media

Where can I get more information?

• Your pharmacist can provide more information about erythromycin and sulfisoxazole.

Nupercainal

Generic Name: dibucaine (Topical application route)

DYE-bue-kane

Commonly used brand name(s)

In the U.S.

• Nupercainal

Available Dosage Forms:

• Cream


• Ointment

Therapeutic Class: Anesthetic, Local

Chemical Class: Amino Amide

Uses For Nupercainal

Dibucaine is used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, minor cuts, or scratches.

Dibucaine belongs to a group of medicines known as topical local anesthetics. It deadens the nerve endings in the skin. This medicine does not cause unconsciousness as general anesthetics do when used for surgery.

This medicine is available without a prescription; however, your doctor may have special instructions on the proper use and dose for your medical problem.

Before Using Nupercainal

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies on the relationship of age to the effects of dibucaine have not been performed in the pediatric population. However, pediatric-specific problems that would limit the usefulness of this medication in children are not expected.

Geriatric

No information is available on the relationship of age to the effects of dibucaine in geriatric patients.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Infection at or near the place of application or


• Large sores, broken skin, or severe injury at the area of application—The chance of side effects may be increased.

Proper Use of Nupercainal

Use this medicine exactly as directed by your doctor or as directed in the package instructions. Do not use it for any other reason without first checking with your doctor. This medicine may cause unwanted effects if it is used too much, because more of it is absorbed into the body through the skin.

Wash your hands with soap and water before and after using this medicine.

Unless otherwise directed by your doctor, do not apply this medicine to open wounds, burns, or broken or inflamed skin.

This medicine should be used only for problems being treated by your doctor or conditions listed in the package directions. Check with your doctor before using it for other problems, especially if you think that an infection may be present. This medicine should not be used to treat certain kinds of skin infections or serious problems, such as severe burns.

Be careful not to get any of this medicine in your nose, mouth, and especially in your eyes, because it can cause severe eye irritation. If any of the medicine does get on these areas, wash the area with water for at least 15 minutes and check with your doctor right away.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For topical dosage form (ointment):
  
  • For pain and itching caused by minor skin conditions:
    
    • Adults—Apply to the affected area three or four times a day as needed. The largest amount that may be used in a 24-hour period is 30 grams (g), but much smaller amounts are usually enough.
    
    
    • Children 2 years of age and older—Apply to the affected area three or four times a day as needed. Do not use more than 7.5 g in a 24-hour period.
    
    
    • Children younger than 2 years of age—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Nupercainal

If your condition does not improve within 7 days, or if it becomes worse, check with your doctor.

After applying this medicine to the skin of your child, watch the child carefully to make sure that he or she does not get any of the medicine in the eyes or mouth. Dibucaine can cause serious side effects, especially in children, if it gets into the mouth and is swallowed.

Stop using this medicine and check with your doctor right away if you have a skin rash, burning, stinging, swelling, or irritation of your skin.

Do not use cosmetics or other skin care products on the treated skin areas.

Nupercainal Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

• Chest pain


• fast or irregular heartbeat


• tightness in the chest


• unusual warmth or flushing of skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Diarrhea


• eye irritation


• nausea


• skin irritation


• vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Nupercainal side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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More Nupercainal resources

• Nupercainal Side Effects (in more detail)
• Nupercainal Use in Pregnancy & Breastfeeding
• Nupercainal Support Group
• 1 Review for Nupercainal - Add your own review/rating

• Nupercainal topical Concise Consumer Information (Cerner Multum)


• Nupercainal Monograph (AHFS DI)


• Nupercainal Ointment MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Nupercainal with other medications

• Anal Itching
• Burns, External
• Hemorrhoids
• Local Anesthesia